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| Title: | Bioactive compounds from liverworts: Inhibition of lipopolysaccharide-induced inducible NOS mRNA in RAW 264.7 cells by Herbertenoids and Cuparenoids |
| Authors: | Harinantenaina L.
Quang D.N.
Nishizawa T.
Hashimoto T.
Kohchi C.
Soma G.-I.
Asakawa Y. |
| Keywords: | Cuparenoids
Herbertenoids
iNOS
Liverworts
RAW 264.7 cell |
| Issue Date: | 2007 |
| Publisher: | Phytomedicine |
| Citation: | Volume 14, Issue 8-Jul, Page 486-491 |
| Abstract: | The inhibition of lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) by herbertenoids and cuparenoids isolated from liverworts in RAW 264.7 macrophages was evaluated. Among compounds tested, herbertenediol, cuparenediol, 1,2-diacetoxyherbertene and 2-hydroxy-4-methoxycuparene exhibited significant activity. For 2-hydroxy-4-methoxycuparene, chosen as representative compound, the strong inhibitory activity was related to the inhibition on LPS-induced iNOS mRNA. The structure-activity relationship will be discussed. © 2006 Elsevier GmbH. All rights reserved. |
| URI: | http://tainguyenso.vnu.edu.vn/jspui/handle/123456789/12230 |
| ISSN: | 9447113 |
| Appears in Collections: | Articles of Universities of Vietnam from Scopus
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