Some imines and azo compounds containing furoxan and benzene rings have been prepared starting from methylisoeugenol. The structure of reported compounds has been confirmed by elemental analysis, ms, uv, ir, and nmr spectroscopy. It is shown that, on treatment with Na2S 2O4, the nitro group on the benzene ring was reduced to an amino group, but the N→O group of furoxan ring was not. The 1H- and 13C nmr signals are assigned based on their spin-spin splitting patterns, in some cases, NOESY and HMBC spectra are used. The NOESY spectra indicate that the reported imines have E-configuration. Among 8 tested compounds, there are 5 compounds that exhibit anti-microbial activity toward Gr+ S. aureus at concentration 12μg /mL.
