http://tainguyenso.vnu.edu.vn/jspui/handle/123456789/6536 2026-05-21T03:46:51Z 2026-05-21T03:46:51Z Agusa, T. Kunito, T. Fujihara, J. Kubota, R. T.B., Minh P.T., Kim Trang Iwata, H. Subramanian, A. P.H., Viet Tanabe, S. http://tainguyenso.vnu.edu.vn/jspui/handle/123456789/7410 2011-05-10T05:38:34Z 2006-01-01T00:00:00Z

Title: Contamination by arsenic and other trace elements in tube-well water and its risk assessment to humans in Hanoi, Vietnam Authors: Agusa, T.; Kunito, T.; Fujihara, J.; Kubota, R.; T.B., Minh; P.T., Kim Trang; Iwata, H.; Subramanian, A.; P.H., Viet; Tanabe, S. Abstract: Concentrations of As and other trace elements and their association were examined in groundwater (n=25) and human hair (n=59) collected at Gia Lam District and Thanh Tri District, suburban areas of Hanoi, Vietnam, in September 2001. Concentrations of As in the groundwater ranged from.

2006-01-01T00:00:00Z P.M., Giang P.T., Son Matsunami, K. Otsuka, H. http://tainguyenso.vnu.edu.vn/jspui/handle/123456789/7408 2011-05-10T05:31:35Z 2006-01-01T00:00:00Z

Title: Anti-staphylococcal activity of ent-kaurane-type diterpenoids from Croton tonkinensis Authors: P.M., Giang; P.T., Son; Matsunami, K.; Otsuka, H. Abstract: Ent-kaurane-type diterpenpoids 1-11, isolated from the dried leaves of the endemic Vietnamese medicinal plant Croton tonkinensis Gagnep. (Euphorbiaceae), were evaluated for inhibitory activity against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) strains. The most active diterpenoids, 2, 3, and 8, exhibited minimum inhibitory concentrations (MICs) of 32, 500, and 125 ?g/ml, respectively, against MRSA strains. ?? 2005 The Japanese Society of Pharmacognosy and Springer.

2006-01-01T00:00:00Z Lee, J.H. Haeng, S.J. M.G., Phan Jin, X. Lee, S. T.S., Phan Lee, D. Y.S., Hong Lee, K. J.L., Jung http://tainguyenso.vnu.edu.vn/jspui/handle/123456789/7406 2011-05-10T05:25:01Z 2006-01-01T00:00:00Z

Title: Blockade of nuclear factor-?B signaling pathway and anti-inflammatory activity of cardamomin, a chalcone analog from Alpinia conchigera Authors: Lee, J.H.; Haeng, S.J.; M.G., Phan; Jin, X.; Lee, S.; T.S., Phan; Lee, D.; Y.S., Hong; Lee, K.; J.L., Jung Abstract: Nuclear factor-?B (NF-?B) and the signaling pathways that regulate its activity have become a focal point for intense drug discovery and development efforts. NF-?B regulates the transcription of a large number of genes, particularly those involved in immune, inflammatory, and antiapoptotic responses. In our search for NF-?B inhibitors from natural resources, we identified cardamomin, 2?,4?-dihydroxy-6?- methoxychalcone, as an inhibitor of NF-?B activation from Alpinia conchigera Griff (Zingiberaceae). In present study, we demonstrated the effect of cardamomin on NF-?B activation in lipopolysaccharide (LPS)- stimulated RAW264.7 cells and LPS-induced mortality. This compound significantly inhibited the induced expression of NF-?B reporter gene by LPS or tumor necrosis factor (TNF)-? in a dose-dependent manner. LPS-induced production of TNF-? and NO as well as expression of inducible nitric-oxide synthase and cyclooxygenase-2 was significantly suppressed by the treatment of cardamomin in RAW264.7 cells. Also, cardamomin inhibited not only LPS-induced degradation and phosphorylation of inhibitor ?B? (I?B?) but also activation of inhibitor ?B (I?B) kinases and nuclear translocation of NF-?B. Further analyses revealed that cardamomin did not directly inhibit I?B kinases, but it significantly suppressed LPS-induced activation of Akt. Moreover, cardamomin suppressed transcriptional activity and phosphorylation of Ser536 of RelA/p65 subunit of NF-?B. However, this compound did not inhibit LPS-induced activation of extracellular signal-regulated kinase and stress-activated protein kinase/c-Jun NH 2-terminal kinase, but significantly impaired activation of p38 mitogen-activated protein kinase. We also demonstrated that pretreatment of cardamomin rescued C57BL/6 mice from LPS-induced mortality in conjunction with decreased serum level of TNF-?. Together, cardamomin could be valuable candidate for the intervention of NF-?B-dependent pathological condition such as inflammation. Copyright ?? 2006 by The American Society for Pharmacology and Experimental Therapeutics.

2006-01-01T00:00:00Z P.M., Giang P.T., Son Matsunami, K. Otsuka, H. http://tainguyenso.vnu.edu.vn/jspui/handle/123456789/7404 2011-05-10T05:16:46Z 2006-01-01T00:00:00Z

Title: New diarylheptanoids from Amomum muricarpum Elmer Authors: P.M., Giang; P.T., Son; Matsunami, K.; Otsuka, H. Abstract: Two new diarylheptanoids, designated muricarpones A and B, together with three known diarylheptanoids, 1,7-di-(3?,4?-dihydroxyphenyl)-4- hepten-3-one, 1-(3?,4?-dihydroxyphenyl)-7-(4??- hydroxyphenyl)- 4-hepten-3-one, and 1,7-bis(p-hydroxyphenyl)-4-hepten-3-one, were isolated from the rhizomes of Amomum muricarpum ELMER (Zingiberaceae). Their structures were determined using spectroscopic analyses. ?? 2006 Pharmaceutical Society of Japan.

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